"We previously have shown that nona-arginine protein transduction domain (R9-PTD) induced efficient protein-antigen (Ag) transduction of dendritic cells (DCs) in vitro, resulting in the efficient induction of strong Ag-specific immune responses mediated by CD8+ and CD4+ T cells and in superior antitumour effects in vivo in cancer-bearing mice. The Ag-specific immune responses caused by intradermal (i.d.) injections of R9-PTD-containing protein Ags without DC preparation were investigated," scientists in Chuo, Japan report (see also Cancer Vaccines).
"We also investigated the antitumour effects by intratumoral (i.t.) injections of rR9-containing protein Ags. Synthesized …
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